Asian Journal of Research in Chemistry

Sunil Kumar ¹, Surrinder Koul ², Ajay Kumar Meena ³, A. K. Saxena ⁴, O. P. Suri ⁵, K. L. Dhar ⁵

Affiliations
1 Department of Pharmaceutical Chemistry, I. S. F. College of Pharmacy, Moga, 142 001,, IN
2 Department of Bio-organic Chemistry, IIIM, Jammu Tawi 180001, IN
3 National Institute of Ayurvedic Pharmaceutical Research, Moti Bagh Road, Patiala, IN
4 Division of Pharmacology, IIIM, Jammu Tawi, 180001, IN
5 Department of Pharmaceutical Chemistry, I. S. F. College of Pharmacy, Moga, 142 001, IN

Abstract

Plants, source of various bioactive compounds have played crucial role in development of several clinically useful anticancer agents' viz., vincristin, vinblastin, camptothecin derivatives and taxol. Combretastatin, a potent anticancer molecule was first isolated from plant. In this continuation a series of combretastatin analogues has been synthesized on the basis of our butterfly model with two wings as aryl groups and connecting carbon chain as the body. In present study we have synthesized combretastatin analogues of different substitutions, showed potent anticancer activity against different cell lines in different fashion according to substitution. Compound 6 showed marked anticancer activity against colo-205 cell lines (colon cancer).

Keywords

Combretastatin, Antitumor, Phenyl Acetic Acid, Tubulin Inhibitor.

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Ajay Kumar Meena ¹, Uttam Singh ², Arjun Singh ³, Sudeep Mishra ³, M. M. Rao ¹, M. M. Padhi ³, Ramesh Babu ³, A. Gaurav ²

Affiliations
1 National Institute of Ayurvedic Pharmaceutical Research, Patiala- 147001, Punjab, IN
2 School of Pharmaceutical Sciences, Shobhit University, Meerut, UP, IN
3 Central Council for Research in Ayurveda and Siddha (CCRAS), Janakpuri, Delhi-110058, IN

Abstract

Vitex negundo Linn (Five-leaved chaste tree), Hindi-Nirgundi, Sanskrit-Sindhuvara, Tamil and Malyalam-Vennochi, Telugu-Nalla vavili and Punjabi-Marwan (Family: Verbenaceae), is an important medicinal plant found throughout India. All parts of this plant especially the leaf and ischolar_main extracts are being used in various formulations in Ayurveda and Unani systems of medicine. Vitex negundo Linn is pungent, bitter and astringent in taste and according to Ayurveda , it alleviates vata and kapha doshas, but aggravates pitta dosha. It possesses light and dry attributes. Its leaves and seeds are widely used externally for rheumatism and inflammations of joints and also reported to have insecticidal properties. Internally, decoction of its leaves is taken as diuretic, expectorant, vermifuge, tonic and febrifuge. The chemical components of the essential oil of leaf isolated from the plant are used to treat colds and coughing spells. Vitex negundo Linn is used in Classical Ayurvedic Preparations like Nirgundi kalka, Nirgundi ghrta, Nirgundi kvatha, Vranasodhana taila, Visagarbha taila etc. The evaluation studies of Pharmacopoeial standards, phytochemical parameters suggested that the observed physiochemical parameters are of great value in quality control and formulation development of Vitex negundo Linn. Physicochemical parameters like preliminary characteristics, toxic heavy metals, and aflatoxin analysis were carried out. The study revealed that the results on different parameters of the crude drug will be useful in identification and control of adulterations.

Keywords

Ayurveda, Vitex negundo Linn, Toxic Metals, Aflatoxin and Quality Control.

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